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dc.creatorNyberg, O.en_US
dc.creatorRico, A.en_US
dc.creatorGuinée, J.B.en_US
dc.creatorHenriksson, P.J.en_US
dc.date.accessioned2021-07-13T08:07:37Z
dc.date.available2021-07-13T08:07:37Z
dc.identifier.citationNyberg, O. Rico, A. Guinée, J. B. et al. Characterizing antibiotics in LCA—a review of current practices and proposed novel approaches for including resistance. Int J Life Cycle Assess (2021). https://doi.org/10.1007/s11367-021-01908-yen_US
dc.identifier.issn1614-7502en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12348/4788
dc.description.abstractPurpose With antibiotic resistance (ABR) portrayed as an increasing burden to human health, this study reviews how and to what extent toxicological impacts from antibiotic use are included in LCAs and supplement this with two novel approaches to include ABR, a consequence of antibiotic use, into the LCA framework. Methods We review available LCA studies that deal with toxicological aspects of antibiotics to evaluate how these impacts from antibiotics have been characterized. Then, we present two novel approaches for including ABR-related impacts in life cycle impact assessments (LCIAs). The first approach characterizes the potential for ABR enrichment in the environmental compartment as a mid-point indicator, based on minimum selective concentrations for pathogenic bacteria. The second approach attributes human health impacts as an endpoint indictor, using quantitative relationships between the use of antibiotics and human well-being. Results and discussion Our findings show that no LCA study to date have accounted for impacts related to ABR. In response, we show that our novel mid-point indicator approach could address this by allowing ABR impacts to be characterized for environmental compartments. We also establish cause-efect pathways between antibiotic use, ABR, and human well-being that generate results which are comparable with USEtox and most endpoint impact assessment approaches for human toxicology. Conclusions Our proposed methods show that currently overlooked impacts from ABR enrichment in the environment could be captured within the LCA framework as a robust characterization methodology built around the established impact model USEtox. Substantial amounts of currently unavailable data are, however, needed to calculate emissions of antibiotics into the environment, to develop minimum selective concentrations for non-pathogenic bacteria, and to quantify potential human health impacts from AB use.en_US
dc.formatPDFen_US
dc.languageenen_US
dc.publisherSpringer (part of Springer Nature)en_US
dc.rightsCC-BY-4.0en_US
dc.sourceInternational Journal of Life Cycle Assessment;(2021)en_US
dc.subjectlcaen_US
dc.subjectresistanceen_US
dc.subjecthuman health impactsen_US
dc.subjectusetoxen_US
dc.titleCharacterizing antibiotics in LCA—a review of current practices and proposed novel approaches for including resistanceen_US
dc.typeJournal Articleen_US
cg.contributor.crpFISHen_US
cg.contributor.crpDRYLAND CEREALS AND LEGUMESen_US
cg.coverage.regionGlobalen_US
cg.subject.agrovocantibioticsen_US
cg.subject.agrovocamren_US
cg.subject.agrovoctoxicologyen_US
cg.subject.agrovocantimicrobialsen_US
cg.contributor.affiliationWorldFishen_US
cg.contributor.affiliationThe University of Tokyoen_US
cg.contributor.affiliationUniversity of Pisa, Department of Agricultural, Food and Environmenten_US
cg.contributor.affiliationStockholm Universityen_US
cg.contributor.affiliationIMDEAen_US
cg.contributor.affiliationCavanilles Institute of Biodiversity and Evolutionary Biology, University of Valenciaen_US
cg.contributor.affiliationInstitute of Environmental Sciences- Leiden Universityen_US
cg.contributor.affiliationStockholm Resilience Centreen_US
cg.contributor.affiliationBeijer Institute of Ecological Economicsen_US
cg.identifier.statusOpen accessen_US
cg.identifier.ISIindexedISI indexeden_US
cg.description.themeMiscellaneous themesen_US
dc.identifier.doihttps://dx.doi.org/10.1007/s11367-021-01908-yen_US
cg.creator.idPatrik John Gustav Henriksson: 0000-0002-3439-623Xen_US


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