View Item 
    •   WorldFish Repository Home
    • WorldFish Community
    • Sustainable aquaculture
    • View Item
    •   WorldFish Repository Home
    • WorldFish Community
    • Sustainable aquaculture
    • View Item
    • Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12348/4949

    A major quantitative trait locus affecting resistance to Tilapia lake virus in farmed Nile tilapia (Oreochromis niloticus)

    Thumbnail

    Abstract
    • Enhancing host resistance to infectious disease has received increasing attention in recent years as a major goal of farm animal breeding programs. Combining field data with genomic tools can provide opportunities to understand the genetic architecture of disease resistance, leading to new opportunities for disease control. In the current study, a genome-wide association study was performed to assess resistance to the Tilapia lake virus (TiLV), one of the biggest threats affecting Nile tilapia (Oreochromis niloticus); a key aquaculture species globally. A pond outbreak of TiLV in a pedigreed population of the GIFT strain was observed, with 950 fish classified as either survivor or mortality, and genotyped using a 65 K SNP array. A significant QTL of large effect was identified on chromosome Oni22. The average mortality rate of tilapia homozygous for the resistance allele at the most significant SNP (P value = 4.51E−10) was 11%, compared to 43% for tilapia homozygous for the susceptibility allele. Several candidate genes related to host response to viral infection were identified within this QTL, including lgals17, vps52, and trim29. These results provide a rare example of a major QTL affecting a trait of major importance to a farmed animal. Genetic markers from the QTL region have potential in marker-assisted selection to improve host resistance, providing a genetic solution to an infectious disease where few other control or mitigation options currently exist.
    • External link to download this item: https://dx.doi.org/10.1038/s41437-021-00447-4
    Collections
    • Sustainable aquaculture [2460]
    Date
    • 2021
    Author
    • Barria, A.
    • Trinh, T.Q.
    • Mahmuddin, M.
    • Penaloza, C.
    • Papadopoulou, A.
    • Gervais, O.
    • Chadag, V.
    • Benzie, J.
    • Houston, R.
    Author(s) ORCID(s)
    • Vishnumurthy Mohan Chadaghttps://orcid.org/0000-0002-2574-284X
    • John Benziehttps://orcid.org/0000-0001-9599-8683
    Subject(s)
    • genome-wide association studies; quantitative trait; Fish
    AGROVOC Keywords
    • genetic markers; quantitative trait loci; animal breeding
    Type
    • Journal Article
    Publisher
    • Springer Nature [academic journals on nature.com] (Fully open access journals)
    Metadata
    Show full item record


    Copyright © 2018 WorldFish
    Contact Us | Send Feedback
    Powered by CodeObia
     

     

    Browse

    All of WorldFish RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Copyright © 2018 WorldFish
    Contact Us | Send Feedback
    Powered by CodeObia