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dc.creatorBarria, A.en_US
dc.creatorTrinh, T.Q.en_US
dc.creatorMahmuddin, M.en_US
dc.creatorPenaloza, C.en_US
dc.creatorPapadopoulou, A.en_US
dc.creatorGervais, O.en_US
dc.creatorChadag, V.en_US
dc.creatorBenzie, J.en_US
dc.creatorHouston, R.en_US
dc.identifier.citationBarría, A. Trịnh, T. Q. Mahmuddin, M. et al. A major quantitative trait locus affecting resistance to Tilapia lake virus in farmed Nile tilapia (Oreochromis niloticus). Heredity 127, 334–343 (2021).
dc.description.abstractEnhancing host resistance to infectious disease has received increasing attention in recent years as a major goal of farm animal breeding programs. Combining field data with genomic tools can provide opportunities to understand the genetic architecture of disease resistance, leading to new opportunities for disease control. In the current study, a genome-wide association study was performed to assess resistance to the Tilapia lake virus (TiLV), one of the biggest threats affecting Nile tilapia (Oreochromis niloticus); a key aquaculture species globally. A pond outbreak of TiLV in a pedigreed population of the GIFT strain was observed, with 950 fish classified as either survivor or mortality, and genotyped using a 65 K SNP array. A significant QTL of large effect was identified on chromosome Oni22. The average mortality rate of tilapia homozygous for the resistance allele at the most significant SNP (P value = 4.51E−10) was 11%, compared to 43% for tilapia homozygous for the susceptibility allele. Several candidate genes related to host response to viral infection were identified within this QTL, including lgals17, vps52, and trim29. These results provide a rare example of a major QTL affecting a trait of major importance to a farmed animal. Genetic markers from the QTL region have potential in marker-assisted selection to improve host resistance, providing a genetic solution to an infectious disease where few other control or mitigation options currently exist.en_US
dc.publisherSpringer Nature [academic journals on] (Fully open access journals)en_US
dc.sourceHeredity;127,(2021) Pagination 334,343en_US
dc.subjectgenome-wide association studiesen_US
dc.subjectquantitative traiten_US
dc.titleA major quantitative trait locus affecting resistance to Tilapia lake virus in farmed Nile tilapia (Oreochromis niloticus)en_US
dc.typeJournal Articleen_US
cg.subject.agrovocgenetic markersen_US
cg.subject.agrovocquantitative trait locien_US
cg.subject.agrovocanimal breedingen_US
cg.contributor.affiliationUniversity of Edinburgh, College of Medicine & Veterinary Medicine, The Roslin Instituteen_US
cg.identifier.statusOpen accessen_US
cg.identifier.ISIindexedISI indexeden_US
cg.contribution.worldfishauthorTrinh, T.Q.en_US
cg.contribution.worldfishauthorMahmuddin, M.en_US
cg.contribution.worldfishauthorChadag, V.en_US
cg.contribution.worldfishauthorBenzie, J.en_US
cg.description.themeSustainable aquacultureen_US
cg.creator.idVishnumurthy Mohan Chadag: 0000-0002-2574-284Xen_US
cg.creator.idJohn Benzie: 0000-0001-9599-8683en_US

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