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dc.creatorDev, V.K.en_US
dc.creatorNeeraj, S.en_US
dc.creatorAnutosh, P.en_US
dc.creatorThangaraj, S.R.en_US
dc.creatorChadag, V.en_US
dc.creatorKV, R.en_US
dc.creatorPravata, P.K.en_US
dc.date.accessioned2021-11-29T05:57:02Z
dc.date.available2021-11-29T05:57:02Z
dc.date.issued2021en_US
dc.identifier.citationDev Kumar Verma, Neeraj Sood, Anutosh Paria, T. R. Swaminathan, C. V. Mohan, K. V. Rajendran, P. K. Pradhan, Reassortment and evolutionary dynamics of tilapia lake virus genomic segments, Virus Research, Volume 308, 2022, 198625, ISSN 0168-1702, https://doi.org/10.1016/j.virusres.2021.198625.en_US
dc.identifier.issn0168-1702en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12348/4967
dc.description.abstractThe tilapia lake virus (TiLV), a highly infectious negative-sense single-stranded segmented RNA virus, has caused several outbreaks worldwide since its first report from Israel in 2014, and continues to pose a major threat to the global tilapia industry. Despite its economic importance, little is known about the underlying mechanisms in the genomic evolution of this highly infectious viral pathogen. Using phylogenomic approaches to the genome sequences of TiLV isolates from various geographic regions, we report on the pervasive role of reassortment, selection, and mutation in TiLV evolution. Our findings provided the evidence of genome-wide reassortment in this newly discovered RNA virus. The rate of non-synonymous (dN) to synonymous (dS) substitutions was less than one (dN/dS = 0.076 to 0.692), indicating that each genomic segment has been subjected to purifying selection. Concurrently, the rate of nucleotide substitution for each genomic segment was in the order of 1–3 × 10−3 nucleotide substitutions per site per year, which is comparable to the rate of other RNA viruses. Collectively, in line with the results of the previous studies, our results demonstrated that reassortment is the dominant force in the evolution and emergence of this highly infectious segmented RNA virus.en_US
dc.formatPDFen_US
dc.languageenen_US
dc.publisherElsevier (12 months)en_US
dc.rightsCopyrighted; all rights reserveden_US
dc.sourceVirus Research;308,(2021)en_US
dc.subjectgenomeen_US
dc.subjecttilapia lake virus (tilv)en_US
dc.subjectsubstitution rateen_US
dc.subjectFishen_US
dc.titleReassortment and evolutionary dynamics of tilapia lake virus genomic segmentsen_US
dc.typeJournal Articleen_US
cg.contributor.crpFISHen_US
cg.coverage.countryIndiaen_US
cg.coverage.regionSouthern Asiaen_US
cg.subject.agrovocselectionen_US
cg.subject.agrovocmutationen_US
cg.contributor.affiliationICAR-Central Institute of Fisheries Education, Versova, Andheri (W)en_US
cg.contributor.affiliationPeninsular and Marine Fish Genetic Resources Centre, ICAR-NBFGR, CMFRI Campusen_US
cg.contributor.affiliationICAR-National Bureau of Fish Genetic Resourcesen_US
cg.contributor.affiliationWorldFishen_US
cg.identifier.statusLimited accessen_US
cg.identifier.ISIindexedISI indexeden_US
cg.contribution.worldfishauthorChadag, V.en_US
cg.description.themeSustainable aquacultureen_US
dc.identifier.doihttps://dx.doi.org/10.1016/j.virusres.2021.198625en_US
cg.creator.idVishnumurthy Mohan Chadag: 0000-0002-2574-284Xen_US


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