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dc.creatorNeeraj, S.en_US
dc.creatorDev, V.K.en_US
dc.creatorAnutosh, P.en_US
dc.creatorShrish, Y.C.en_US
dc.creatorManoj, Y.K.en_US
dc.creatorMegha, B.K.en_US
dc.creatorSaurav, K.en_US
dc.creatorThangaraj, S.R.en_US
dc.creatorChadag, V.en_US
dc.creatorKV, R.en_US
dc.creatorPravata, P.K.en_US
dc.date.accessioned2021-03-10T13:36:33Z
dc.date.available2021-03-10T13:36:33Z
dc.date.issued2021en_US
dc.identifier.citationSood, N. Verma, D. K. Paria, A. et al. (2021). Transcriptome analysis of liver elucidates key immune-related pathways in Nile tilapia Oreochromis niloticus following infection with tilapia lake virus. Fish and Shellfish Immunology, 111: 208-219.en_US
dc.identifier.issn1050-4648en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12348/4555
dc.description.abstractNile tilapia (Oreochromis niloticus) is one of the most important aquaculture species farmed worldwide. However, the recent emergence of tilapia lake virus (TiLV) disease, also known as syncytial hepatitis of tilapia, has threatened the global tilapia industry. To gain more insight regarding the host response against the disease, the transcriptional profiles of liver in experimentally-infected and control tilapia were compared. Analysis of RNASeq data identified 4640 differentially expressed genes (DEGs), which were involved among others in antigenprocessing and presentation, MAPK, apoptosis, necroptosis, chemokine signaling, interferon, NF-kB, acute phaseresponse and JAK-STAT pathways. Enhanced expression of most of the DEGs in the above pathways suggests anattempt by tilapia to resist TiLV infection. However, upregulation of some of the key genes such as BCL2L1 inapoptosis pathway; NFKBIA in NF-kB pathway; TRFC in acute phase response; and SOCS, EPOR, PI3K and AKT inJAK-STAT pathway and downregulation of the genes, namely MAP3K7 in MAPK pathway; IFIT1 in interferon;and TRIM25 in NF-kB pathway suggested that TiLV was able to subvert the host immune response to successfullyestablish the infection. The study offers novel insights into the cellular functions that are affected following TiLVinfection and will serve as a valuable genomic resource towards our understanding of susceptibility of tilapia toTiLV infection.en_US
dc.formatPDFen_US
dc.languageenen_US
dc.publisherElsevieren_US
dc.rightsCopyrighted; all rights reserveden_US
dc.sourceFish and Shellfish Immunology;111,(2021) Pagination 208,219en_US
dc.subjectrna-seqen_US
dc.titleTranscriptome analysis of liver elucidates key immune-related pathways in Nile tilapia Oreochromis niloticus following infection with tilapia lake virusen_US
dc.typeJournal Articleen_US
cg.contributor.crpFISHen_US
cg.coverage.countryIndiaen_US
cg.coverage.regionSouthern Asiaen_US
cg.subject.agrovoctranscriptomeen_US
cg.subject.agrovocimmunityen_US
cg.subject.agrovocoreochromis niloticusen_US
cg.subject.agrovoctilapia lake virusen_US
cg.subject.agrovocliveren_US
cg.contributor.affiliationWorldFishen_US
cg.contributor.affiliationICAR-National Bureau of Fish Genetic Resourcesen_US
cg.contributor.affiliationICAR-Central Institute of Fisheries Education, Versova, Andheri (W)en_US
cg.contributor.affiliationPeninsular and Marine Fish Genetic Resources Centre, ICAR-NBFGR, CMFRI Campusen_US
cg.identifier.statusTimeless limited accessen_US
cg.identifier.ISIindexedISI indexeden_US
cg.contribution.worldfishauthorChadag, V.en_US
cg.description.themeSustainable aquacultureen_US
dc.identifier.doihttps://dx.doi.org/10.1016/j.fsi.2021.02.005en_US
cg.creator.idVishnumurthy Mohan Chadag: 0000-0002-2574-284Xen_US


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